Pipeline
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In The Pipeline
Derek Lowe’s commentary on drug discovery and the pharma industry. An editorially independent blog, all content is Derek’s own, and he does not in any way speak for his employer. If you have any questions for Derek, please email him at derekb.lowe@gmail.com.
I’ve done a number of Fourth of July posts here on the site over the years. I'm not actually linking to any of them, because I find them unfortunately painful to look back on - this one, as they say, hits differently. I’ve spent the year so far watching the country of my birth slide disastrously off the rails, and with my own chosen profession (scientific and medical research) showing up as a very
Like anyone in drug discovery, I’m always ready to hear about new assays that will let us tackle unusual and difficult targets in as close to real-world living systems as possible. We have a lot of assay technologies already, but no one can say that we’ve got things covered as well as we’d like. There are always tradeoffs! Just to pick a few, you have to balance sensitivity, reproducibility, fidel
OK, this one’s going to be a bit chem-geeky, but it shows what you can accomplish when you really bear down on a particular reaction. This paper is looking at a constant concern in scaling up reactions: thermodynamics and heat transfer. I’ve written about this sort of things before, and the problem is pretty easy to grasp. A lot of reactions give off some amount of heat as they proceed, b
I feel a bit odd writing this entry today, since our HHS secretary is busy tearing down the US vaccination system. But if you’re going to stay on the side of science and evidence, you have to go where the evidence takes you: it would be another betrayal of reason to pretend the Every Vaccine Everywhere works perfectly every time, because that isn’t the case. But I have to say up front - even thoug
This is part of a series of posts on the attacks on federally-funded research in the US. The previous installment is here. I have only begun writing this post, and I can already tell that I’m going to have to go back over it and edit it for coherence and to clear out the expletives. But then again, why should I? The barbarians are running through the streets, looting and breaking things into piec
I enjoyed this new paper very much, because I’m a fan of (1) odd natural products, (2) analytical techniques that give us solid three-dimensional structures, and especially (3) when those techniques can be accomplished on a very small scale and without having to strain to produce large perfect crystals. I’ve written several times here about micro-ED (electron diffraction) for just these reasons, b
There have been plenty of headlines (well, in the places where chemistry news makes headlines!) about this new paper which reports the discovery of hexanitrogen. That’s a new allotrope of the element, the first charge-neutral nonradical form of nitrogen to be isolated since good old nitrogen gas itself, and it’s not like people haven’t been trying. A cyclic N5 anion definitely exists, although pre
Here’s a look at a source of experimental variability that some chemists might not have considered: magnetic stirring bars. For the non-chemists in the audience, these are a standard bit of lab equipment - they’re just small magnets encased in (typically) a polyfluorocarbon (Teflon) coating. You drop one into your reaction flask and then put them over a “stir plate”, which has a rotating magnet of
This is provocative look here at Science at the intersection of AI-driven drug discovery and patent law. There has been a lot of talk about this over the last few years, and some of it has been from me. Some of the fundamental concepts of patent law could be affected by widespread use of AI techniques, with “Non-obviousness” at the head of the list. Who’s to say what obvious to a machine-learning
Morphine is one of the most famous alkaloids in the world, and like most such structures, it has chirality (handedness), with five chiral centers that are fixed in one particular arrangement. Plants only produce morphine that will rotate plane-polarized light in the left-hand direction, thus (-) morphine, but most organic and medicinal chemists have rarely run this thought experiment: what if you
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